An advanced innovative controlled nucleation technology capable of producing sterile cryogenic kryo fog and circulating it with a lyophiliser chamber to ensure reliable and prompt top-down nucleation of the vial-contained pharmaceutical formulations at an optimal temperature. KRYOSEQ^® technology is applicable to IMA Life’s range of freeze dryers, such as LYOMAX, LYOFAST, MINIMAX, LYOFAST MINI and MINIFAST (KRYOSEQ LAB^®).

KRYOSEQ^® nucleation for laboratories, KRYOSEQ LAB^®, is a compact, portable system fitting in limited laboratory space equipped with an automated, user-friendly system with minimal user input required and with updated enclosure enabling improved internal access. All operations are conducted at or below atmospheric pressure and it is compatible with freeze dryers of various makes and models.

CUMULUS® brings a new era of cryogenic cooling to pharmaceutical freeze-drying. By replacing traditional mechanical refrigeration with a liquid nitrogen-based system, CUMULUS® delivers high-level performance, reliability and sustainability. This technology enables low temperatures, fast cooling rates and simple operation.

The search for a low environmental impact, high performance, safe, refrigeration system for freeze drying is now complete. The KRYOAIR air refrigeration system circulates ultra low-temperature air as the refrigerant. It is composed of three parts: an expander integrated with a compressor (compression and expansion), a primary cooler (heat dissipation) and a heat-recovery heat exchanger (heat recovery).

To better cope with peak heat demands, the KRYOAIR system combines a novel thermal energy storage system, along with the turbo compressor expander.  The energy storage system has no moving parts, is compact, and environmentally friendly. The combination offers a high performance, efficient refrigeration system that has zero environmental impact caused by using refrigerants with a global warming potential.

A smart miniature mass spectrometer, a non-invasive technique capable of performing quantitative real-time process-relevant measurements. A multipurpose device designed for use in pharma freeze-dryers, it detects contaminants and process gases at concentrations down to ppm levels.

IMA Life’s patented FUSION^TM shelves are built in-house by a fully automated manufacturing process, ensuring higher quality and increased process reliability. They are designed and finished to improve the lyophilisation outcome and to reduce operating costs and energy consumption. The FUSION^TM shelves are lighter and more resistant than conventional solutions and offer enhanced heat transfer properties. FUSION^TM shelves are an integral part of the entire range of IMA Life freeze dryers.

The machine offers the most comprehensive range of custom-built freeze-dryers for those who require more than a standard solution. Lyomax can provide the answer from 1 m² to 100 m² applying state-of-the-art engineering in vacuum, refrigeration, stoppering and heat-transfer technology.

Freeze-drying has important applications in the pharmaceutical and biotechnology industries, and is now a standard procedure used to stabilise, store or increase the shelf life of drug products and other biologicals. 
A pre-engineered, cost-effective, reliable and efficient industrial freeze dryer, LYOFAST keeps freeze-drying competitive as a pharmaceutical processing step.
For either bulk format or liquid in vials, ampoules or trays, the LYOFAST units are designed for the freeze-drying of high value products, such as vaccines, antibiotics, cytostatics, biologicals, hormones, active ingredients, and reactives.

MINIMAX is a GMP small-scale freeze dryer developed to address the demands involved in handling small production batches. Similarly to the LYOMAX industrial freeze dryer, MINIMAX benefits from all-round performance, a high level of redundancy and various configurable options making it a reliable and versatile solution for each application. MINIMAX can be integrated with isolation technology and automatic vial-loading systems. The unit is pre-arranged to support the processing of non-aqueous solvents and high potent products. Available in six configurations with shelf areas from 1.0 up to 3.9 m², MINIMAX ensures an ice condenser capacity ranging from 29 to 78 kg with minimum condenser temperatures of – 75°C.

LYOFAST MINI range of freeze dryers responds to the growing demand for small-batch production of high-value products or personalized medicines. It offers a reliable, GMP-compliant compact freeze dryer that meets the highest standards of quality and sterility. To cope with market drivers, LYOFAST MINI series of freeze dryers have been developed to be suitable for the following applications: small batch production, clinical trials, product development and process cycle optimization, up scaling of the process for later use in production plants.

Freeze-drying technology comes in all sizes and MINIFAST is the ideal size for R&D requirements of a laboratory environment. MINIFAST is a laboratory solution designed according to the same technical performance and quality standards as a production-scale lyophiliser. The product is available in MINIFAST 04 and MINIFAST 10 configurations, with shelf areas of 0.4 and 1.1 m². MINIFAST ice condenser capacity range from 8 kg to 20 kg, with minimum condensing temperatures of -85°C as standard.