Leakage into a lyophiliser may originate from various sources. The leak rate should be monitored periodically to maintain the integrity of the system and, should the rate exceed specified limits, to determine the actual leak site for repair purposes.
Leakage into a lyophiliser may originate from various sources. The leak rate should be monitored periodically to maintain the integrity of the system and, should the rate exceed specified limits, to determine the actual leak site for repair purposes.
QUANTUM smart miniature Mass Spectrometer is a non-invasive technique capable of performing quantitative real-time process-relevant measurements. A multipurpose device designed for use in pharma freeze dryers, it detects contaminants and process gases at concentrations down to ppm levels. Not only does this allow for silicone oil detection and for non-aqueous solvent detection, but QUANTUM can also be used as a system leak detection tool and as a process analytical tool for scale-up and development studies.
Robust, reliable and ultra-compact, QUANTUM houses a pre-calibrated modular sensor comprising a long-lasting ion source, a multichannel quadrupole array mass filter and the Faraday Cup detector.
TECHNICAL DATA QUANTUM | |
Measurement specification |
Conditions/units |
Installation | Complete in 2 working days |
Mass Range | 1-100 amu |
Mass Resolution | FWHM: 1 (m/z = 28) |
Communication interfaces | Ethernet (wi-fi upon request) |
Mass number stability | 0.1 amu |
Sensitivity | 5e-6 A/Torr |
Linear response range | 1e-9 Torr – 5e-3 Torr at 400 µA emission for N2 |
Minimum detectable partial pressure |
1e-9 Torr for N2 / 1e-8 Torr for He / 1e-9 Torr for Ar |
Minimum detectable concentration (LoD) |
1 ppm for N2 at 1 mTorr |
Maximum operational pressure |
5e-3 Torr for N2 |
Scan speed per amu |
10 msec/amu to 10 sec/amu adjustable |
Sampling pressure range |
1e-5 Torr – 1e+3 Torr (8 decades P range) |
Operating temperature |
10°C to 35°C |
Electron energy |
25 V – 100 V (70 V default setting) |
Emission current |
0.01 – 1 mA (0.4 mA default setting) |
Accuracy |
< 1% of reading |
Startup-up time |
3′ from out of the box |
Weight |
9 kg |
Ambient temperature |
5°C to 35°C, no air conditioning |
Power consumption | DC 24V, <100 W |