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LYOMAX
Industrial Freeze Dryer

Freeze-drying involves removal of solvent such that the molecular structure of the active ingredient of the drug is least disturbed, thus providing a dried drug product that is stable over time.

Freeze-drying involves removal of solvent such that the molecular structure of the active ingredient of the drug is least disturbed, thus providing a dried drug product that is stable over time.

Beyond Limits

Although one of the oldest techniques in the pharmaceutical industry for the preservation of unstable materials, there has been an increasing demand for lyophilized products and equipment, in particular in the last decade. In fact today, about half of all sterile injectables are lyophilized.

The freeze-drying process of today demands increased process control, with reduced processing time augmented with upgrades in equipment to remain compliant with a changing regulatory landscape. To accommodate such growth, IMA LIFE uses its in-depth process knowledge to make freeze drying faster, safer, cheaper, and compatible with all industry requirements and challenges.

LYOMAX configurable options and custom designs provide the optimal solution for each application.

LYOMAX meets the highest possible technical requirements, the strictest standards of the global licensing authorities, and comply with all the current guidelines such as GAMP, cGMP, FDA etc.

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Sustainability

IMA Lyomax freeze dryers embody the requirements of the pharmaceutical industry for faster, safer, cheaper and more ecologically friendly processes:
• The IMA Life patented FusionTM shelves reduce energy consumption typically in heating, cooling and steam sterilization thus achieving a reduction in energy costs and fast temperature response. The FusionTM shelves allow for a 20% reduction in weight leading to reduced energy consumption during freeze drying and sterilization.
• PAT tools reduce overall process time and energy consumption.
• IMA Life is developing innovative eco-friendly refrigeration for freeze dryers, the KryoAir. The KryoAir is a new 100% green refrigeration technology using the ultimate natural refrigerant “air”. The system is based on a series of compression/cooling/ expansion steps of air, which can be cooled to a temperature as low as -100° C.

IMA Life
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IMA Life North America

LYOMAX Highlights

1.
Machine sizes from 1 m2 to 100 m2.
2.
Configurations including integral condenser, external condenser, two-story and pass through designs.
3.
Two stage reciprocating semi-hermetic/screw compressors/liquid nitrogen refrigeration system.
4.
Shelf cooling to -55/70°C and condenser cooling to -75/120°C. HFC/LN2 refrigerants.
5.
Integrated automatic, semi-automatic and manual loading/unloading systems.
6.
Vacuum measurements with capacitance manometers.
7.
VERISEQ® advanced technology using sterile liquid nitrogen to control the nucleation process during pharmaceutical freeze drying.
The Lyomax series offers the most comprehensive range of custom-built freeze-dryers for those who require more than a standard solution. Lyomax can provide the answer from 1 m2 to 100 m2 applying state-of-the-art engineering in vacuum, refrigeration, stoppering and heat-transfer technology.
  • Technical Data
  • Machine Layout
Model Nominal Shelf area manual loading (m2) Nominal Shelf area manual loading (m2) Shelf spacing range (mm) Shelf size (wxd) manual loaded (mm) Shelf size (wxd) autoloaded (mm) Condenser capacity (kg @ 12.7 mm ice) Typic Refrigeration configuration Vacuum pumping capacity (m3/h)
Lyomax 1 1.4 NA 80 to 140 455 x 165 NA 27 2 x 5 hp 1 x 28
Lyomax 3 2.8 NA 80 to 140 615 x 915 NA 67 2 x 8 hp 1 x 40
Lyomax 5 5 4.6 80 to 140 615 x 915 914 x 837  107 2 x 12 hp 2 x 80
Lyomax 7 7.8 7.3 80 to 140 915 x 1220 914 x 1141 148 2 x 16 hp 2 x 80
Lyomax 10 10 9.4 80 to 140 915 x 1220 914 x 1141 218 2 x 20 hp 2 x 175
Lyomax 15 14.5 13.9 80 to 140 1220 x 1220 1220 x 1142 294 2 x 30 hp** 2 x 275
Lyomax 20 20.5 19.4 80 to 140 1220 x 1524 1220 x 1445  398 3 x 30 hp* 2 x 275
Lyomax 25 26 24.7 80 to 140 1220 x 1524 1220 x 1445  532 3 x 30 hp* 2 x 275
Lyomax 30 30,2 28.6 80 to 140 1524 x 1524 1524 x 1445 644 3 x 50 hp* 2 x 275
Lyomax 35 36,3 34,7 80 to 140 1524 x 1830 1524 x 1751 756 3 x 50 hp* 2 x 275
Lyomax 40 41,8 40,0 80 to 140 1524 x 1830 1524 x 1752 756 4 x 50 hp* 2 x 275
LYOMAX Layout

LYOMAX Gallery

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LYOMAX rear side
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Autoloading slot door
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Shelf stack
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Shelf guiding
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Chamber door locking
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Internal overview
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Frontal view
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Shelf stack collapse