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CDC LINE
Continuous Direct Compression
CDC is a very lean, efficient and flexible tablet-manufacturing technology that, in combination with PAT, allows easy adoption of a QbD approach.
CDC is a very lean, efficient and flexible tablet-manufacturing technology that, in combination with PAT, allows easy adoption of a QbD approach.
Continuous Direct Compression
CDC provides excellent operation performance; the system is designed to achieve a state of control very quickly and avoid any waste during startup and shutdown phases. A CDC line has a lean configuration which promotes smooth product flow, consisting of unit operations to configure a set of feeders (up to 6 units), horizontal mixer, tablet press and integrated control system. All the parts of a CDC line are dimensioned according to a required production throughput. Average throughput recommended for pharmaceutical manufacturing is in the range 20-100 kg/h.
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Sustainability
The Continuous Manufacturing projects aim at improving process efficiency and minimizing energy consumption. Although the development of Continuous Manufacturing process and technology is a challenge, it will have significant advantages including costs and risks reduction at any stage, either during the engineering phase or in daily production with the opportunity of higher flexibility.
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Production Plant
IMA Active
CDC LINE Highlights
1.
Feeding blending unit for continuous accurate dosing and mixing of the ingredients.
2.
Direct feeding of tablet press by gravity.
3.
Blend uniformity control on the tablet press feed frame thanks to integrated NIR sensor.
4.
Integration with MAESTRO control system of all the unit operations.
Thanks to the large portfolio of material handling equipment, IMA Active can offer a wide variety of solutions for product transfers from one unit operation to the other.
