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LYOFAST
Industrial freeze dryer
Freeze drying of pharmaceuticals and biopharmaceuticals has become a routine procedure, which leads to an increase in product stability. LYOFAST is the pre-engineered cost-effective, reliable and efficient standard solution.
Freeze drying of pharmaceuticals and biopharmaceuticals has become a routine procedure, which leads to an increase in product stability. LYOFAST is the pre-engineered cost-effective, reliable and efficient standard solution.
More than a standard solution
Freeze-drying has important applications in the pharmaceutical and biotechnology industries, and is now a standard procedure used to stabilise, store or increase the shelf life of drug products and other biologicals.
A pre-engineered, cost-effective, reliable and efficient industrial freeze dryer, LYOFAST keeps freeze-drying competitive as a pharmaceutical processing step.
For either bulk format or liquid in vials, ampoules or trays, the LYOFAST units are designed for the freeze-drying of high value products, such as vaccines, antibiotics, cytostatics, biologicals, hormones, active ingredients, and reactives.
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Sustainability
IMA LYOFAST freeze dryers embody the requirements of the pharmaceutical industry for faster, safer and cost-efficient processes:
• The IMA Life patented FUSIONTM shelves reduce energy consumption typically in heating, cooling and steam sterilization thus achieving a reduction in energy costs and fast temperature response. The FUSIONTM shelves allow for a 20% reduction in weight leading to reduced energy consumption during freeze drying and sterilization.
• PAT tools enable better process understanding and optimization.
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Production Plant
IMA Life Beijing
LYOFAST Highlights
1.
Freeze dryers for small-scale and large-scale production, with shelf areas ranging from 1 m2 to 40 m2 and more.
2.
Various configurations of chambers and condensers to suit any layout.
3.
Best-in-class refrigeration systems with two-stage, semi-hermetic reciprocating compressors, screw compressors, or cold nitrogen gas.
4.
Direct expansion condensers or fluid circulation condensers.
5.
Ready to be integrated with KRYOSEQ® for nucleation control.
6.
IMA Life’s patented FUSION™ brazed shelves and FUSION PLUS™ shelves with non-stick coating technologies.
7.
A wide range of features and options designed to meet the demands of complex drug formulations, including high-potent products and flammable solvents.
8.
State-of-the-art control system, advanced instrumentation, with a high level of redundancy for optimum process control and enhanced quality of the final product.
By constructing the LYOFAST freeze dryer from a series of standard modules, IMA Life is able to compress project schedules and reduce lead times, even for large capacity equipment, while delivering significant cost savings.
IMA Life's FUSION™ - FUSION PLUS™ shelves
- Technical Data
- Machine Layout
| LYOFAST 1-15 TECHNICAL DATA | ||||||||||
| Model | Chamber/ condenser geometry |
Number of shelves up to |
Vial pack area up to Manual loading (m2) |
Vial pack (wxd) Manual loading (mm) |
Vial pack area up to Auto loading (m2) |
Vial pack (wxd) Auto loading (mm) |
Condenser |
Compressor config. |
LN2 config |
KryoAir config |
| LYOFAST 1 | Cylindrical integral |
5 | 1.4 | 455 x 615 | n/a | n/a | 32 | 2 x 5Hp Bitzer | LF25/12 | 1 x 23T-0 |
| LYOFAST 3 | Cylindrical integral |
5 | 2.8 | 615 x 916 | n/a | n/a | 67 | 2 x 8Hp Bitzer | LF25/12 | 1 x 23T-0 |
| LYOFAST 5 | Cylindrical integral |
9 | 5.1 | 615 x 916 | n/a | n/a | 103 | 2 x 16Hp Bitzer / 2 x 30Hp Mycom |
LF25/12 | 1 x 23T-1 |
| LYOFAST 5 | Rectangular integral |
7 | 5.9 | 916 x 916 | 5.4 | 914 x 837 | 103 | 2 x 16Hp Bitzer / 2 x 30Hp Mycom |
LF25/12 | 1 x 23T-1 |
| LYOFAST 5 | Rectangular cylindrical |
7 | 5.9 | 916 x 916 | 5.4 | 914 x 837 | 103 | 2 x 16Hp Bitzer / 2 x 30Hp Mycom |
LF25/12 | 1 x 23T-1 |
| LYOFAST 7 | Cylindrical integral |
7 | 7.8 | 916 x 1,220 | n/a | n/a | 148 | 2 x 20Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 1 x 23T-1 |
| LYOFAST 7 | Rectangular integral |
5 | 10.4 | 1,220 x 1,220 | 7 | 1,218 x 1,141 | 148 | 2 x 20Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 1 x 23T-1 |
| LYOFAST 7 | Rectangular cylindrical |
7 | 12.3 | 916 x 1,220 | 7.3 | 914 x 1,141 | 148 | 2 x 20Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 1 x 23T-1 |
| LYOFAST 10 | Rectangular integral |
7 | 16.3 | 1,220 x 1,220 | 9.7 | 1,218 x 1,141 | 186 | 2 x 20Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 1 x 23T-1 |
| LYOFAST 10 | Rectangular cylindrical |
11 | 17.9 | 916 x 1,220 | 11.5 | 914 x 1,141 | 194 | 2 x 20Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 1 x 23T-1 |
| LYOFAST 15 | Rectangular integral |
7 | 12.3 | 1,524 x 1,524 | 15.4 | 1,522 x 1,445 | 273 | 2 x 30Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 2 x 23T-1 |
| LYOFAST 15 | Rectangular cylindrical |
12 | 17.9 | 1,220 x 1,220 | 16.7 | 1,218 x 1,141 | 273 | 2 x 30Hp Bitzer / 2 x 30Hp Mycom |
LF50/20 | 2 x 23T-1 |
| LYOFAST 20-40 TECHNICAL DATA | ||||||||||
| Model | Chamber/ condenser geometry |
Number of shelves up to |
Vial pack area up to Manual loading (m2) |
Vial pack (wxd) Manual loading (mm) |
Vial pack area up to Auto loading (m2) |
Vial pack (wxd) Auto loading (mm) |
Condenser |
Compressor config. |
LN2 config |
KryoAir config |
| LYOFAST 20 | Rectangular integral / cylindrical |
12 | 22.3 | 1,220 x 1,524 | 21.1 | 1,218 x 1,145 | 378 | 3 x 30Hp Bitzer / 2 x 30Hp Mycom |
LF100/50 | 1 x 80T-0 |
| LYOFAST 25 | Rectangular integral / cylindrical |
14 | 26 | 1,220 x 1,524 | 24.6 | 1,218 x 1,145 | 476 | 3 x 30Hp Bitzer / 2 x 50Hp Mycom |
LF100/50 | 1 x 80T-1 |
| LYOFAST 30 | Rectangular integral / cylindrical |
14 | 32.5 | 1,524 x 1,524 | 30.8 | 1,522 x 1,445 | 553 | 3 x 30Hp Bitzer / 2 x 50Hp Mycom |
LF100/50 | 1 x 80T-1 |
| LYOFAST 35 | Rectangula integral / cylindrical |
13 | 36.3 | 1,524 x 1,830 | 34.7 | 1,522 x 1,751 | 635 | 4 x 30Hp Bitzer / 2 x 50Hp Mycom |
LF100/50 | 1 x 80T-1 |
| LYOFAST 40 | Rectangular integral / cylindrical |
17 Manual 15 Auto |
47.4 | 1,524 x 1,830 | 40 | 1,522 x 1,751 | 731 | 4 x 30Hp Bitzer / 2 x 50Hp Mycom |
LF100/50 | 2 x 80T-0 |
| Minimum shelf temperature (5cst/1/6cst oil) | -55C/-60C | -65C | -60C | |||||||
| Minimum condenser temperature | -75C | -100C | -75C | |||||||
LYOFAST Gallery
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LYOFAST side main door
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LYOFAST general view open door
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Internal view with vials on shelf
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Internal view
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Vial loading
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Detail of vials arranged on shelf
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Vial loading overview
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Vials on shelves
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Speculum
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Shelves side view
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Shelf detail