CAPABILITIES
Freeze-drying cycle development/feasibility studies with the customer’s product.
Development and testing of new process analytical technologies.
Ice Fog Nucleation (Veriseq®) feasibility studies with the customer’s product.
Scale-up and technology transfer.
Hands-on freeze-drying equipment and process trainings for customers.
EQUIPMENT LIST
Pilot Scale 2.3 m2 (Lyofast)
Laboratory Scale 0.3 m2 (Minifast)
Laboratory Scale 0.1 m2 (Epsilon)
Spray Freeze Dryer
KEY IN-HOUSE CAPABILITIES
Freeze Drying Microscopy
Differential Scanning Calorimetry
Karl Fischer Titration (Coulometric)
Loss on Drying Balance
PAT
Tunable Diode Laser Absorption Spectroscopy (TDLAS)
Residual Gas Analyzer (RGA)
Wireless Process Monitoring
Heat Flux Sensors
Pirani / Capacitance Manometer
Thermocouples
INSTRUMENTATION
Scanning Electron Microscopy
X-Ray Diffraction
Gas Chromatography
Mass Spectrometry
High Pressure Liquid Chromatography
Ultra-high Pressure Liquid Chromatography
Preventative maintenance programmes, validation support, control system upgrades, freeze-drying cycle development, training, upgrades and refurbishments. These are just some of the value-adding services we can offer.
Our highly skilled professionals have extensive experience gained in the field of parenteral development and facility operation. Their technical expertise includes freeze-drying technology, aseptic processing, formulation, filtration science and sterilization.
Developing a revolutionary freeze-drying technology always requires some form of lateral thinking. One challenge was to find a way of making the freeze-dried product compatible with a variety of containers.
Especially since the planet is faced with a pandemic, freeze drying has come under a lot of attention. Efficiency, simple supply chains, a need for large volumes are factors that have driven the development of technologies such as those of our LYnfinity spray freeze-drying solution. One issue we need to re-think was the heat and mass transfer.
Developing a revolutionary freeze-drying technology always requires some form of lateral thinking. One challenge was to find a way of making the freeze-dried product compatible with a variety of containers. Typically, freeze-dried products were handled in vials or on bulk trays limiting the use of alternate emerging containers.