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TILE-X
Gloveless, small-batch RTU fill-finish solution

Ground-breaking fill-finish process innovation, designed to handle Ready-To-Use components using magnetic levitation. Suitable for high-value pharmaceuticals such as biopharmaceuticals and ATMPs with a focus on cell and gene therapies.

Ground-breaking fill-finish process innovation, designed to handle Ready-To-Use components using magnetic levitation. Suitable for high-value pharmaceuticals such as biopharmaceuticals and ATMPs with a focus on cell and gene therapies.

Innovation goes magnetic.

TILE-X extends the concept of modularity, unprecedented in the aseptic fill-finish process. Based on magnetic levitation technologies, TILE-X enables frictionless component handling with zero risk of particulate generation.

TILE-X is equipped with floating shuttles achieved via magnetic levitation that transport single vials or complete RTU nests, programmed to move freely and capable of executing diverse trajectories according to specific pharmaceutical product requirements.

Thanks to the flexibility of the magnetic transport system, TILE-X allows implementation of a gloveless modular construction philosophy, where each module handles a single phase of the process: introduction of RTU components, delidding and denesting, filling with 100% check-weighing, capping, and crimping with up to 40 units/min. performance.

TILE-X is made of multiple, independent modules, each representing a Grade A gloveless isolated chamber. In order to provide maximum sterility assurance, the modules are designed to maximise first air protection and avoid cross-contamination risks, thanks to the ability to manage pressure cascades between modular chambers, sealing them individually with automatic air-tight doors.

Changing the viable particle plates is performed automatically with no need for manual manipulation. The loading of autoclaved stoppering and capping size parts is performed by RTP port and canister in TILE-X’s preparation module. This dedicated module avoids complex protective bag procedures.

Feeding of Ready-To-Use components into the TILE-X modules can be carried out with No-Touch-Transfer technology or other compact solutions for RTU tub/tray surface decontamination, such as IMA Life’s decontamination technology.

 

 

 

IMA Life
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IMA Life

TILE-X Highlights

1.
Innovative, fully flexible and adaptable to production process with magnetic levitation for a particle-free transport system.
2.
Fully gloveless, closed isolator also suitable for installation in grade D. No human intervention required during production.
3.
Automatic machine set-up and human-less positioning of size parts, including filling needles and all product contact parts.
4.
Modular design with integrated isolator shell, minimising layout size, building and cleanroom requirements, facilitating fast production scale out.
5.
Automatic handling of EM plates during set-up and production phase, independently of batch duration. Easy integration with real-time viable monitoring system.
6.
Performance of up to 40 pcs/min with RTU syringes, vials, pre-capped cartridges (made of glass or polymers).
7.
Different compounding recipes can be selected for one or more mixable pharmaceutical specialities, also inside each single filled vial.
8.
Minimization of product loss. Filling circuit fully configurable to product specifications (suspension, cold filling, etc.). Different dosing systems available (peristaltic, volumetric or time-pressure).
TILE-X is ideal for advanced biopharmaceuticals such as ATMPs and cell and gene products. Automation, gloveless concept and magnetic levitation technology ensure high process flexibility and perfect sterility assurance, avoiding any operator-related risks.
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