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SENTINEL LYO
Cloud-based platform for FD data analytics system

Lyophilisation is a time-consuming, energy-intensive and expensive process requiring constant monitoring of the system and process variables. Sentinel LYO provides advanced analytical capabilities through strategically located sensors inside your freeze-dryer.

Lyophilisation is a time-consuming, energy-intensive and expensive process requiring constant monitoring of the system and process variables. Sentinel LYO provides advanced analytical capabilities through strategically located sensors inside your freeze-dryer.

Analyse Data, provide predictions, define future.

In a freeze-drying process, each component such as compressors or vacuum pumps has a direct impact on a drug product’s critical quality attributes (CQAs). Process parameters such as shelf temperature and chamber pressure have a similar relationship to product quality. The design and operation of the SENTINEL-LYO Data Analytics platform is based on such regulatory guidance.

IMA Life
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IMA Life

SENTINEL LYO Highlights

1.
Compressors: refrigeration system signals pattern recognition to identify anomalies from normal operating behavior.
2.
Chamber: in-process monitoring of chamber conditions with recipe specific models.
3.
Shelves: tracking historical shelf heat load and temperature spread to alert the user to any deviations in trends.
4.
Vacuum System: holistic sensor framework will analyse the vacuum and booster pump performance by trending and tracking patterns in vibration, current, temperature and pressure sensor data.
5.
Condenser: algorithms designed to predict occurrences of condenser overload conditions to alert production staff of the overall condenser performance.
Sentinel LYO platform is build surrounding an overall health management principle, where process and equipment knowledge can be combined to provide system performance outputs to the user. This involves an interaction between three core areas: Sense, Analyse & Predict.