Raising productivity and reducing downtime is now possible in a continuous aseptic process, with constant monitoring from fermentation to final packaging.
Raising productivity and reducing downtime is now possible in a continuous aseptic process, with constant monitoring from fermentation to final packaging.
Lynfinity spray-freeze-drying process features a controlled spray of liquid product into a cryogenically cooled freezing chamber. The resultant frozen particles of the liquid product are freeze-dried in the drying module. The drying chamber contents are both transported and heated to promote rapid sublimation and prevent agglomeration.
The continuous spray-freeze-drying process starts with bulk liquid product and ends with the discharge of dried particles, featuring total containment from formulation to powder filling. This enables higher sterility assurance levels, whereas traditional freeze-drying requires additional external material handling, for example during filling. Upon completion of drying, the uniform, dried spherical product allows for the use of a variety of containers (vials, syringes, inhalation systems etc.).
Continuous Manufacturing in pharmaceutical industry has a great potential in terms of sustainability as the reduced plant footprint leads to space and energy-savings.
Lynfinity is a Continuous Manufacturing process developed for freeze drying.
Lynfinity LAB features a controlled spray of liquid product into a cryogenically cooled freezing chamber. The resultant frozen particles are stored in a cooled canister to transfer for drying in a traditional lab freeze dryer.
The Laboratory Lynfinity can be a useful tool for introduction to spray freeze drying, technology evaluation, and process development, with a low barrier to entry.