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LYNFINITY
Continuous Aseptic Spray-Freeze-Drying

Raising productivity and reducing downtime is now possible in a continuous aseptic process, with constant monitoring from fermentation to final packaging.

Raising productivity and reducing downtime is now possible in a continuous aseptic process, with constant monitoring from fermentation to final packaging.

LYNFINITY is just a drop away

LYnfinity spray-freeze-drying process features a controlled spray of liquid product into a cryogenically cooled freezing chamber. The resultant frozen particles of the liquid product are freeze-dried in the drying module. The drying chamber contents are both transported and heated to promote rapid sublimation and prevent agglomeration.

The continuous spray-freeze-drying process starts with bulk liquid product and ends with the discharge of dried particles, featuring total containment from formulation to powder filling. This enables higher sterility assurance levels, whereas traditional freeze-drying requires additional external material handling, for example during filling. Upon completion of drying, the uniform, dried spherical product allows for the use of a variety of containers (vials, syringes, inhalation systems etc.).

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LYNFINITY Highlights

1.
Designed for continuous process from fermentation to final packaging
2.
Greater throughput flexibility: minimization of scale up and scale down challenges
3.
Better quality attributes: improved product uniformity through a gentle drying process
4.
Total containment from formulation to powder filling: higher sterility assurance level (SAL)
5.
Higher productivity and lower downtime: increased concentration, reduced drying time, no vapour flow limitation, direct heat transfer from shelf minimal product, no product resistance from cake thickness
6.
Reduced running OPEX costs: reduced operating and utilities costs and reduced number of operators
7.
Reduced CAPEX i.e. capital investments: equipment foot print reduction and no loading system requirements
8.
Faster reconstitution time: increased Specific Surface Area (SSA) leading to faster reconstitutions
Continuous operation dictates controlled movement that allows sufficient resident time for drying. However, it is imperative that the transport be gentle on the product.

LYNFINITY LAB

LYNFINITY LAB features a controlled spray of liquid product into a cryogenically cooled freezing chamber. The resultant frozen particles are stored in a cooled canister to transfer for drying in a traditional lab freeze dryer.

The Laboratory LYnfinity can be a useful tool for introduction to spray freeze drying, technology evaluation, and process development, with a low barrier to entry.

LYNFINITY Thumbnail

LYNFINITY Gallery

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Drying chamber shelf stack
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Frozen particles on shelf stack
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Frozen particles on shelf stack_detail
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Traditional lyo cake
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the spraying process
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The freezing process
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The drying process
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Lynfinity spheres