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Continuous Manufacturing
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Ready for the next step.

Welcome to the future, the new world where production goes by the name integration. This is the new pharmaceutical production frontier, where Prexima and Croma are one.

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Feasability Studies of Continuous Manufacturing of Injection Molding tablets.

In the last decade, there has been a noticeable shift to move pharmaceutical manufacturing from a more traditional batch configuration to a continuous mode.
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Perfect adaptability for truly continuous production.

Using thorough process control, Continuous Manufacturing (CM) improves production in the pharmaceutical sector in terms of power, effectiveness and safety.
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Prexima and Croma, integrated technologies for Continuous Manufacturing.

Welcome to the future, the new world where production goes by the name integration. Where a single system manages transformation from powder to tablet.
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Face the future • Continuous Manufacturing Experience

Continuous Manufacturing is no longer a niche market.
At IMA, we believe that continuous processing improves the quality of pharmaceuticals in terms of potency, effectiveness and safety.

Explore our webinar series dedicated to Continuous Manufacturing.

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Continuous Manufacturing Survey

The increasing interest of the pharmaceutical industry in Continuous Manufacturing aims at achieving total quality through a flexible and sustainable production.
Our team is ready to welcome the demand for innovation coming from companies and stakeholders, working together to design the future of pharmaceutical manufacturing.

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CROMA Outline

Continuous Manufacturing supports improvement of pharmaceutical products in terms of potency, effectiveness, and safety, by means of accurate process control. Croma is IMA’s first step towards continuous.

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These are the #CromaStories

Croma is an attempt to get less conventional and be less mainstream. It means not following someone else’s path, but going our own way instead, a new way. After all, IMA has a duty to innovate.

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Watch CROMA Stories

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What is CROMA in your view?

“Croma is incredible: it has something that other machines simply don’t. What I find really interesting and unique about this machine is that the drawer-based system for transferral between the modules is really simple”.

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What is CROMA in your view?

“Croma is an idea that we’ve watched come up from nothing and really take shape. The ultimate goal is to make the process perfectly repetitive… and Croma manages it!”

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What is CROMA in your view?

“Croma is a machine that is complex yet simple at the same time. For example, at the start I thought we’d have needed some kind of incredible computer to handle it. But in the end, all we had to do was expand our perspective and look at a new control system”.

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What is CROMA in your view?

“Croma is one of the most important R&D projects that I have ever managed. Because it’s a big challenge. It represents a break with the past and a completely new beginning”.

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What is CROMA in your view?

“Croma is an attempt to get less conventional and be less mainstream. It means not following someone else’s path, but going our own way instead, a new way. After all, IMA has a duty to innovate”.

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What is CROMA in your view?

“What I love about Croma is its extreme versatility, its ability to establish productive connections in any direction. I remember the interest that the concept created at Interpack 2017 and Achema 2018. I saw such curiosity in the eyes of our clients…”

From our event Can't Stop the future
Spotlight on Continuous Manufacturing in Oral Solid Dosage forms.

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IMA’s way from batch to continuous

Guia Bertuzzi is Product Manager at IMA Active division since 2005. She has been working in mixing, granulation and powders handling systems for more than 20 years. She is expert in pharmaceutical engineering and process for Active Pharmaceutical Ingredients and Oral Solid Dosage forms.

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Continuous Manufacturing: state of the art, challenges, and future prospects

Bernhardt L. Trout is Professor of Chemical Engineering at MIT and Director of Novartis-MIT Center for Continuous Manufacturing. His research focuses on the development of advanced manufacturing processes and rational tools for formulation and product design.

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Global regulatory implementation on Continuous Manufacturing

Moheb M. Nasr managed the CDER Pharmaceutical Analysis Program at the US FDA for four years and had the lead of the CDER/FDA CMC Regulatory Program for more than eight years. He also worked for GSK as VP Global CMC Strategy. In 2018 he started his own consultancy business.

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Integrated Continuous Manufacturing (ICM) of medicines

How drug quality can be monitored and improved via fully automated and Integrated Continuous Manufacturing (ICM).

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Dynamic process models for continuous encapsulation processes

Keirnan LaMarche is Senior Principal Scientist at Patheon. He is an expert in solid dosage form design, continuous manufacturing, and he received his PhD in chemical Engineering from Rutgers University in 2008. He gained 10 years of experience in solid dosage form development at Bristol-Myers Squibb.

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Making the switch from batch to Continuous Manufacturing: an industrial perspective

Giustino Di Pretoro is Associate Director at Janssen Pharmaceutica, a Johnson & Johnson Company. He is a subject matter expert and drug product development lead for Continuous Manufacturing, and coordinator for a series of academic collaborations within the field of continuous.

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How to implement and validate Continuous Manufacturing of direct compression tablets: challenges and opportunities

Frank Streil is Director Technical and Scientific Affairs at Teva/RATIOPHARM. His main interests and experience are in the field of process development and validation as well as in new technologies, PAT and Continuous Manufacturing.

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Control strategies for Continuous Manufacturing

Alan Johnston is Senior Life Sciences Consultant at Emerson’s Global consultancy team. He has spent a majority of his career in the Life Sciences industry with a broad range of technical and business experience across production, automation and digitalization including Primary, Secondary and Vaccine manufacture. He has previously held senior technical roles at Siemens, Novartis Vaccines and GSK.